Drug-selective pressure effect on HIV integrase mutations in antiretroviral naïve and experienced patients
نویسندگان
چکیده
AMA Basimi P, Farrokhi M, Ghanbari Dehghan Manshadi SA, Naghib Baesi K. Drug-selective pressure effect on HIV integrase mutations in antiretroviral naïve and experienced patients. & AIDS Review. International Journal of HIV-Related Problems. 2023;22(2):99-103. doi:10.5114/hivar.2023.127727. APA Basimi, P., Farrokhi, M., Ghanbari, Manshadi, S. A., Naghib, Baesi, (2023). Problems, 22(2), 99-103. https://doi.org/10.5114/hivar.2023.127727 Chicago Parya, Molood Maryam Seyed A Kazem Baesi. 2023. "Drug-selective patients". Problems 22 (2): Harvard S., pp.99-103. MLA Parya et al. patients." vol. 22, no. 2, 2023, pp. Vancouver S,
منابع مشابه
Drug- Resistance- Associated Mutations and HIV Sub-Type Determination in Drug-Naïve and HIV-Positive Patients under Treatment with Antiretroviral Drugs
Abstract Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents. Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were d...
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Viruses were sequenced from 75 antiretroviral therapy (ARV)-naïve and from 75 ARV-treated patients who subsequently received a raltegravir-containing regimen. No major integrase inhibitor (INI)-resistance mutations were present in the 150 integrase (IN) sequences. Four ARV-naïve (5.3%) and two ARV-treated patients (2.7%) had one of the following minor INI-resistance mutations: L74M, E157Q, G163...
متن کاملPrevalence of HIV drug-resistance mutations in HIV-infected Mexican patients heavily experienced to antiretroviral therapy
Results We assessed 178 subjects, mean age (SD ±) of our subjects was 41.9 ± 11.9; 91% where male, who failed 2 to 15 ART regimen (median 5). CDC status was A 20%, B 21% and C 59%; 4% were coinfected with HBV and 2% were infected with HCV. Month median drug exposure was 121 (range 12-219). Ninety nine (55.6%) had triple class drug mutations, 170 (95.5%) had NRTI mutations, 113 (63.5%) had NNRTI...
متن کاملHIV-1 integrase variability and relationship with drug resistance in antiretroviral-naive and -experienced patients with different HIV-1 subtypes.
H-932. American Society for Microbiology, Washington, DC, USA. 10 Nouhin J, Donchai T, Hoang KT et al. Natural polymorphisms of HIV-1 CRF01_AE integrase coding region in ARV-naive individuals in Cambodia,Thailand and Vietnam: an ANRS AC12 working group study. Infect Genet Evol 2011; 11: 38–43. 11 Wainberg MA, Brenner BG. Role of HIV subtype diversity in the development of resistance to anti...
متن کاملDrug-Resistant HIV-1 RT Gene Mutations in Patients under Treatment with Antiretroviral Drugs (HAART) in Iran
Abstract Background and Objective: Highly Active Antiretroviral Therapy (HAART) can effectively prevent the progression of HIV-1 replication and increase life expectancy. There are numerous causes of treatment failure and the leading one is drug resistance. Thus, we aimed to determine the HIV RT gene drug resistance mutations in patients treated with antiretroviral medications. Material...
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ژورنال
عنوان ژورنال: HIV and AIDS Review
سال: 2023
ISSN: ['1730-1270', '1732-2707']
DOI: https://doi.org/10.5114/hivar.2023.127727